NBU SAV

Impact of angiogenesis inhibition on postnatal neurogenesis

Annotation:

In spite of intensive research an accumulating knowledge, the mechanisms of postnatal neurogenesis regulation are still poorly understood. Newborn cells arising in the subventricular zone (SVZ) migrate long distances in the rostral migratory stream (RMS) to the olfactory bulb (OB).

Recent findings have shown that neuroblasts in the RMS might use for their migration specifically arranged blood vessels as a physical substrate. Under pathological conditions neuroblasts are able to migrate from the SVZ toward brain injuries also using blood vessels for their navigation. It is also well known that angiogenesis and neurogenesis are interconnected.

The aim of our project is to examine the impact of angiogenesis inhibition on cell migration in the system SVZ/RMS/BO under physiological conditions. The next aim is to examine the impact of the excitotoxic brain injury on the cell migration outside of the neurogenic areas toward the lesion site under normal conditions as well as following angiogenesis inhibition.