NBU SAV

Blood as a medium providing the tolerance in a brain after global and focal ischemic attack

Annotation:

Presented project is focused on the study of mechanisms inducting ischemic tolerance in the models of global and focal brain ischemia in rat. The main goal is determination of mechanism providing information transfer that participates on the creation of brain tolerance to ischemic condition.

Based on the knowledge that ischemic tolerance can be induced in any tissue or organ using the broad spectrum of indirect interventions, we will focus on the study of circulating blood and its compartments as the only one medium that fits to the access flexibility.

In addition to the source identification and identity of factor inducing ischemic tolerance, our intention is to describe how is this information transmitted to the nerve tissue (overcoming natural barriers), and how the machinery itself triggers induction of the tolerance in different neuronal populations affected by ischemia. For fulfillment the objectives we want to use complex strategy involving several biochemical, proteomic and histological approach.