Institute of Neurobiology of Slovak Academy of Sciences (INB SAS) was created by the transformation of the former institute of experimental Biology of Slovak Academy of Sciences (founded 1964) and it was officially registered from January 1st, 1977.


The main goal of SAS:

The study of the nervous tissue and central nervous system under physiological and pathological conditions (basic and clinical neurobiology). Current trends and developments were reflected in a multidisciplinary approach to the problems studied in INB SAS.


The scientific research has been specifically aimed to the study if ischemic and traumatic injury in the central nervous system and the regeneration possibilities and various protective effects.



Till the year 1996, INB SAS was divided into five departments - neuromorphology, neurochemistry, neurobiophysics, neurotransplantation, neurophysiology. From 1997 the Institute has been divided into laboratories - neuropathology and neuroprotectivity, electron-microscopy, historadiography, histochemistry and imunohistochemistry, molecular neurobiology, proteosynthesis, lipid metabolism, neurotransmitters and neuromodulators.


Directors of INB SAS:

Prof. Jozef Maršala, MD, DSc. - until 1999,
Ivo Vanický, DVM, PhD -  1999 - 2011
Nadezda Lukacova, DSc - 2011 - 2015
Ján Gálik, PhD - since 2015


Successful projects:

The role of free radicals in ischemia-reperfusion cerebral injury. The role of spinal cord postischemic neuronal hyperactivity in reperfusion injury. Neuroprotection if ischemically and traumatically injured neuronal structures. Study of the possibilities for influencing the acute postischemic inhibition of protein synthesis causing the death of dysfunction of neurons. Transplantability and regenerability of the nervous tissue.


Spinal postischemic neuronal hyperactivity: Role in reperfusion injury. Pathophysiological mechanisms underlying spinal cord infarct, ischemic penumbra and experimental neuroprotective adjuncts. Spinal cord injury – modulation of secondary processes and their therapeutic effect. The role of early postischemic disturbances in protein synthesis of the functional and metabolic recovery of CNS.


Comparison between relative resistant and selectively vulnerable brain regions. Stem cells as a potential source of functional recovery in adult rat brain. Comparison of ischemic and denervation induced cortical plasticity. The mechanisms influencing spinal cord nonciceptive transmission at acute/chronic pain state and possible pharmacological treatment.


554 papers in extenso mostly in the world scientific journals - Neuroscience, J. Neurosci., J. Neurocytol., Eur. J. Neurosci., Neurosci. Lett., J. Cereb. Blood Flow Metab., J. Histochem. Cytochem., Brain Res., J. Surg. Res., J. Neurosurg., Stroke, Neuroreport, Rest. Neurol. Neurosci., Neurology, J. Comp. Neurol., Cell. Biol., Exp. Neurol., J. Neurochem., Neurochem. Res., Neuropharmacology, Pain, Mol. Chem. Neuropathol., Progress Neurobiol., Acta Histochem., Brain Res. Bull., Neurosci. Res. Comm., Cell. Mol. Neurobiol., J.Neurotrauma, Neurochem. Int., J. Neurosci. Res., Physiol. Res., Dev. Brain Res., Cell, J. Cell Biol., J. Neurosci. Meth., Biologia, etc.



Maršala, J. 1983: Human Tissues and Organs, Veda, Bratislava, 605 pp.
Maršala, J. 1985: Systematic and functional Neuroanatomy, Osveta, Martin, 784 pp.
Skorodenský, M. 1991: analysis of Tropical Psychological Risk Factors in Ischemic Heart Disease, Veda, Bratislava, 193 pp.
Chavko, M. & Maršala, J. 1993: mechanism of Ischemic Damage of the Spinal Cord. Veda, Bratislava, 117 pp.
Ferčáková, A. 1997: Morphology of Sensory ganglia, Veda, Bratislava, 93 pp.
Žigová, T., Snyder, EY., Sanberg PR, 2002: Neural Stem cells for brain and spinal cord repair. Humana Press, Totowa, New Jersey,, ISBN 1-58829-003-4, 429 pp..
Žigová T., Sanberg PR., Sanchez-Ramos JR, 2002: Neural stem cells – methods and protocols. Humana Press, Totowa, New Jersey,, ISBN0-89603-964-1, 381 pp.


The international collaboration:

Institut mozga, Akademia nauk Sovetskovo soyuza, Moscow, Soviet Union (1978 - 1990);
Institute of Physiology, Academy of Sciences of the Czech republic, Prague, Czech Republic;
Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary;
ETEX Corporation, Cambridge, MA, USA;
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA;
Department of Anesthesiology, University of California, San Diego, CA, USA;
Departamento de Bioquimica, Hospital Ramon y Cajal, Madrid, Spain;
Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, Alcala de Henares, Spain;
Academic Medical Center Amsterdam, The Netherlands


A membership in the international scientific societies:

ESN - European Society for Neurochemistry
IBRO - International Brain Research Organization
ENA - European Neuroscience Association
ECRO – European Chemoreception Oganization
ASN - American Society for Neuroscience
ANG - Anatomische Geselschaft
SFN - Society for Neuroscience
International Association for the Study of Pain
American Society for Neural Transplantation and Repair
World Federation of Neurology Commission for Comparative Neuroanatomy
Česká a Slovenská neurochemická spoločnosť